Out of context, anthropocentric and reductionist policies, laws, procedures, processes, fragmentation, borders, boundaries, and manipulation of the environment may cause adaptation in people that is unhealthy and unnatural. Combined with the manufacturing of conditions, manufacturing of judging, manufacturing of hostile environments, pollution exclusion, and survival zone suffering, it creates a cumulatively significant impact that results in the cumulative total pollution exclusion of people. Everyone should be accepted and included from birth, and the environment should be as Natural Earth striving and holistic Humanity striving as possible. People should be considered an integral part of Natural Humanity instead of manipulated with anthropocentric constructs and behavior-altering extreme reductionism. Are we putting people into polluted environments so that they will take on the characteristics of the environment? Why are some people manufactured into being the sum totals of their environment, thus creating unnatural and unhealthy conditions or vice versa into a condition of Holistic, Natural, and Healthy Living? Do the cumulative totality pollution exclusion, survival zone suffering, and cumulative significant impact stressors eventually kill people in a variety of ways?